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The Hilarious Night of Depression
Join host John Moe and his guests, comedian Paul F. Tompkins, musician Aimee Mann, and commentator Ana Marie Cox for a show that is sure to be candid, unpredictable, hilarious, and even inspirational. Info and tickets here.

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The Hilarious World of Depression is made possible by a grant from HealthPartners and its Make It OK campaign, which works to reduce the stigma of mental health. Find out more at
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A show about clinical depression...with laughs? Well, yeah. Depression is an incredibly common and isolating disease experienced by millions, yet often stigmatized by society. The Hilarious World of Depression is a series of frank, moving, and, yes, funny conversations with top comedians who have dealt with this disease, hosted by veteran humorist and public radio host John Moe. Join guests such as Maria Bamford, Paul F. Tompkins, Andy Richter, and Jen Kirkman to learn how they’ve dealt with depression and managed to laugh along the way. If you have not met the disease personally, it’s almost certain that someone you know has, whether it’s a friend, family member, colleague, or neighbor. Depression is a vicious cycle of solitude and stigma that leaves people miserable and sometimes dead. Frankly, we’re not going to put up with that anymore. The Hilarious World of Depression is not medical treatment and should not be seen as a substitute for therapy or medication. But it is a chance to gain some insight, have a few laughs, and realize that people with depression are not alone and that together, we can all feel a bit better.


Gary Gulman Is a Brilliant Comedian and an Ineffective Offensive Lineman

October 30, 2017 · Duration: 46:02 · Play

Although Gary Gulman has been a successful stand-up comedian for decades – with acclaimed specials, a loyal fan base, and appearances on all major late night shows – this was not his original plan. Gary is 6’6” and athletically gifted, he loved basketball, and had a full ride athletic scholarship to a Division 1 program. […]

Aimee Mann Discovers That Having Feelings About Terrible Things Is Perfectly Fine

October 23, 2017 · Duration: 50:03 · Play

Singer/songwriter Aimee Mann has a reputation for making music that is raw, emotional, and sometimes not all that cheerful. In real life, she’s perfectly cheerful – thank you very much – and has traveled a long road of depression, anxiety, a difficult childhood, and writer’s block. Through it all, she’s taken a calm, considered, and […]

John Green Falls Victim to Some Bad Fiction While Writing His New Book

October 16, 2017 · Duration: 56:39 · Play

Author John Green had one of the best-selling books of the last 10 years with The Fault In Our Stars. The problem is, when you write an acclaimed smash hit, everyone wants you to somehow do it again. In attempting to write that follow-up, Green went off the meds he’d been taking for Obsessive-Compulsive Disorder, […]

Neal Brennan Gives Ketamine and Magnetic Impulses a Try

October 9, 2017 · Duration: 50:47 · Play

If you’ve enjoyed any comedy in the last 20 years, there’s a good chance Neal Brennan helped make it. He’s a veteran comic, writer, director, and co-creator, with Dave Chappelle, of the acclaimed Chappelle’s Show. Over the past 20-plus years, he’s also tried everything he could think of to tame his depression. Hear Neal’s epic […]

Margaret Cho Works Out A Lot And Makes People Upset In New Jersey

October 2, 2017 · Duration: 41:18 · Play

She’s one of the most influential and innovative comedians of the last few decades, but before all that, Margaret Cho was a Korean-American girl growing up in the 1970s in San Francisco. We hear about the sometimes very darkly humorous ways her family and culture dealt with depression and suicide, and how she harnessed her […]

Wil Wheaton Is Really Hoping It’s All Worth It

September 25, 2017 · Duration: 49:07 · Play

Wil Wheaton was a child star in Stand By Me, a regular on Star Trek: The Next Generation as a teenager, and has been trying to figure out his role in show business for a long time since then. He was dealing with the pressures of fame and the fickle tastes of Hollywood, all while […]

Episode #PREVIEW: Season 2 starts Sept. 25!

September 18, 2017 · Duration: 3:44 · Play

Season 2 of The Hilarious World of Depression starts on September 25, 2017. Get a jump on it by hearing from some of the comics, actors, authors, and musicians you’ll get to know this season.

Episode #PLACEBO: Imagine Depression as a Person and Describe Them

August 28, 2017 · Duration: 13:23 · Play

What if clinical depression was not just a thing in someone’s brain but an actual other person entirely? What would they look like? Act like? Who would they be? And how would you interact with such a person? It’s a mental exercise that many find helpful in isolating the disease from the self to better […]

Episode #PLACEBO: How to Get Help

August 15, 2017 · Duration: 23:58 · Play

If you are having problems with your mental health, please get help. You’ve heard that before on this show and probably plenty of other places as well. But how do you actually do that? How do you go about finding professional help to get things on a better track? It’s a process that can be […]

Episode #PLACEBO: Hitting the Nail on the Head

July 31, 2017 · Duration: 13:10 · Play

Depression can be really hard to define, making it difficult for anyone who doesn’t have it to be understand it. And that can make the people who do have it feel that much more alone. We asked our listeners what movie, TV show, artwork, or other piece of culture gets depression right. The answers range […]

Episode #PLACEBO: The Things We Tell Ourselves That Help

July 5, 2017 · Duration: 13:04 · Play

There are many ways to address depression: therapy, meds, exercise, music. And then there are our own thoughts. We learn the mantras, reminders, and rituals that some of our listeners use to get through it when Clinny D flares up.

Episode #PLACEBO: Vol. 2 of Listeners’ Favorite Coping Songs

June 19, 2017 · Duration: 21:49 · Play

When clinical depression, the ol’ Clinny D, starts getting the best of our listeners, a lot of them reach for the headphones to fire up some choice tunes. We take another spin through the therapeutic playlist and hear from The Beach Boys, the Grateful Dead, and a Taylor Swift cover you simply must listen to.

Episode #PLACEBO: Listeners’ Favorite Coping Songs

June 5, 2017 · Duration: 16:05 · Play

We asked our listeners to tell us about the songs they use when depression is hitting hard. Take a listen to some of the responses, both the songs themselves and the stories behind them in this highly musical trip through the jukebox that is Clinny D. You won’t often find mix tapes with Doris Day, […]

Episode #PLACEBO: Coping Ideas From a Real Live Sad Clown

May 22, 2017 · Duration: 13:35 · Play

More ideas from listeners for unusual methods they used to address their depression that actually worked. We’ve heard a wide variety of ideas from all over the world, including Jonna Nummela of Helsinki, Finland who tells about her clown alter-ego who takes lumps so Jonna doesn’t have to. We also hear about what Jonna brings […]

Episode #PLACEBO: A Conversation with Ana Marie Cox

May 5, 2017 · Duration: 1:20:08 · Play

It’s a crossover conversation between The Hilarious World of Depression’s John Moe and Ana Marie Cox, host of the podcast With Friends Like These. Both shows traffic in the idea of having more conversations about things that don’t get talked about very often. In that spirit, John and Ana Marie open about some events that […]

Episode #PLACEBO: The Return of Peter Sagal

April 10, 2017 · Duration: 11:38 · Play

Peter Sagal, host of NPR’s Wait Wait…Don’t Tell Me! was our guest on the very first episode of our podcast. He used the occasion to break a long silence and tell the world that he’s struggled with depression, the first time he had told anyone other than a doctor. On this placebo episode, we check […]

Episode #PLACEBO: Billy Joel, Intrusive Thoughts Named Steve, and Nocturnal Carpentry

March 13, 2017 · Duration: 17:55 · Play

THWoD stops by to say hello with a mini-episode. A not-really-an-episode. A placebo. Instead of talking to professional comedians, host John Moe talks to some listeners of the show about their surprisingly amusing tales of struggling with depression. We hear about the power of a pair of concert tickets, a very special friend who isn’t […]

Episode #9: Paul F. Tompkins Sees Dead Grass and Has Screwed Up Relationships

February 6, 2017 · Duration: 53:52 · Play

Comedian and actor Paul F. Tompkins is known for being friendly and delightful both on stage and off. And that’s pretty surprising given that he grew up in a home where his parents slept in separate rooms, each likely struggling with undiagnosed and untreated depression, and conflict and anger were all around. Hear how comedy […]

Episode #8: Baron Vaughn and His Inadvisable All-Cheerio Diet

January 30, 2017 · Duration: 45:35 · Play

The life of a professional comedian and actor can be glamorous at times. You get recognized, go to the occasional celebrity party, maybe have a lot of strangers know your name. But it didn’t feel all that swanky to Baron Vaughn when he was holed up in a Vancouver apartment for days at a time, […]

Episode #7: Jen Kirkman, Bad Therapy, Good Therapy, and Nuclear Invasion

January 23, 2017 · Duration: 42:47 · Play

Before she was a successful LA comic with a new Netflix special, Jen Kirkman was a somewhat confused kid growing up in Boston. Hear how she got screwed up by nuclear war anxiety, found her calling in comedy, and ultimately learned to leverage her creativity and imagination to take on depression and anxiety.